Bromeyal® is a proteolytic enzyme complex isolated from the stem of the pineapple plant which retains its bioactivity following gastrointestinal transit without enteric-coating.
Overview
Bromelain is one of the most popular plant-derived enzymes used by the nutraceutical and food industry due to its broad protein hydrolysis activity over a wide pH range as well as for its numerous health benefits. In particular, if taken between meals it helps to improve joint and muscle comfort, relieves occasional swelling and pain especially following exercise. It can also benefit the immune system and promote gut health. On the other hand, when bromelain is consumed during a meal, it breaks down and digest protein in the stomach.
Due to its protein structure, bromelain is thought to be digested and perhaps loses activity with a potential loss of its anti-inflammatory action during the gastrointestinal transit. As a result, the majority of commercially sold bromelain supplements continue to enteric coat tablets or capsules. To close this formulation gap Giellepi developed Bromeyal®, a premium natural bromelain that does not require enteric coating.
Bromeyal®’s proprietary multi-step extraction and purification process prevent degradation of active proteolytic constituents preserving their biological activity even after gastrointestinal transit and digestion.
Active:
Bromelain NLT 2400 GDU/g
Form:
Fine powder
Recommended daily dosage:
200-800 mg (between meals);
200-2000 mg (with meals)
Applications:
Tablets, capsules, powders
Retains its bioactivity after digestion.
No enteric coating needed.
High potency proteolytic enzyme complex.
Multi-step extraction and purification.
Composition
Bromeyal® is produced using a proprietary extraction and purification process to ensure the utmost purity, quality, and potency. Our aqueous and multi-step extraction process has been developed to prevent enzyme denaturation while preserving the native chemistry of protein digesting enzymes naturally found in pineapple stems. Following oral intake, Bromeyal® maintains its bioactivity and does not need any physical protection (enteric-coating) from the harsh stomach environment.
Applications
- Swelling, occasional pain and inflammation
- Gut health
- Immune support
- Cardiovascular health
- Respiratory health
Preclinical evidence
Anti-inflammatory properties of Bromeyal® following simulated gastrointestinal transit and digestion were investigated in human cell lines derived from stomach, intestinal and chondrocytes.
Results
1. In chondrocytes cell lines, digested Bromeyal® inhibits interleukin 8 (IL-8) expression,
a pro-inflammatory cytokine
2. In intestinal cells, digested Bromeyal® inhibits IL-8 expression
Reference
Bottega et al. Int J Immunopathol Pharmacol. 2021;35:1-9.
Giellepi solutions
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